Health care advances have delivered great benefits to society, bringing material improvements in average life spans and quality of life. Yet these improvements have come at a cost—an ever-expanding portion of the US GDP is being consumed by healthcare expenses. Could technology be part of the solution by enabling delivery of healthcare advances while improving affordability? We have reviewed the evidence, done the math, and identified technology-enabled use cases that could create between $350 billion and $410 billion in annual value by 2025 (out of the $5.34 trillion in healthcare spending projected for that year).